Table 1.
Baseline characteristics of MESA-Angiogenesis cohort (N=1,358)
| Ang1 Tertile | Ang2 Tertile | |||||
|---|---|---|---|---|---|---|
| Low | Middle | High | Low | Middle | High | |
| Protein Range (ng/mL) | (0.3–1.1) | (1.1–1.6) | (1.6–21.2) | (1.4–4.0) | (4.0–5.7) | (5.7–33.8) |
| Age (years) mean ± SD | 62 ± 10 | 60 ± 10 | 61 ± 10 | 59 ± 9 | 61 ± 10 | 63 ± 10 |
| Female % | 55.9 | 50.1 | 51.5 | 44.6 | 53.7 | 60.1 |
| Race/ethnicity % | ||||||
| White | 45.4 | 35.5 | 40.2 | 39.2 | 43.0 | 39.0 |
| Black | 30.4 | 26.9 | 22.9 | 20.8 | 26.6 | 33.4 |
| Hispanic | 13.0 | 22.5 | 27.3 | 19.6 | 19.9 | 23.7 |
| Asian | 11.2 | 15.0 | 9.6 | 20.4 | 10.5 | 3.9 |
| Height (cm) mean ± SD | 167 ± 10 | 166 ± 10 | 166 ± 10 | 167 ± 10 | 166 ± 10 | 166 ± 10 |
| Weight (kg) mean ± SD | 77 ± 17 | 78 ± 16 | 76 ± 16 | 75 ± 15 | 77 ± 16 | 79 ± 17 |
| Education % | ||||||
| No HS diploma | 12.3 | 20.1 | 16.4 | 17.3 | 12.8 | 18.8 |
| HS diploma | 31.8 | 32.9 | 38.2 | 27.5 | 38.0 | 38.1 |
| College degree | 55.9 | 47.0 | 45.4 | 55.2 | 49.2 | 43.2 |
| Smoking status % | ||||||
| Never | 53.0 | 54.3 | 51.3 | 58.1 | 55.0 | 44.8 |
| Former | 39.2 | 34.4 | 35.2 | 36.5 | 36.0 | 36.2 |
| Current | 7.8 | 11.3 | 13.5 | 5.4 | 9.0 | 19.0 |
| Pack years mean ± SD | 11 ± 21 | 9 ± 19 | 11 ± 24 | 7 ± 15 | 9 ± 17 | 16 ± 29 |
| Hypertension % | 43.0 | 44.6 | 43.0 | 38.8 | 40.9 | 51.5 |
| Systolic BP mean ± SD | 126 ± 21 | 125 ± 21 | 125 ± 21 | 122 ± 19 | 125 ± 22 | 128 ± 23 |
| Diabetes % | 11.6 | 11.5 | 11.6 | 7.7 | 10.5 | 16.9 |
| Cholesterol (mg/dl) mean ± SD | 190 ± 33 | 195 ± 33 | 198 ± 33 | 196 ± 31 | 194 ± 33 | 191 ± 36 |
| GFR (ml/min) mean ± SD | 81 ± 17 | 82 ± 18 | 80 ± 16 | 82 ± 16 | 81 ± 16 | 80 ± 19 |
| BNP (pg/ml) mean ± SD | 97 ± 144 | 101 ± 175 | 82 ± 116 | 60 ± 78 | 85 ± 127 | 141 ± 206 |
| Medication use % | ||||||
| Beta blocker | 7.8 | 9.7 | 10.5 | 6.9 | 8.3 | 13.2 |
| ACEI/ARB | 17.2 | 15.0 | 18.1 | 14.8 | 13.7 | 22.3 |
| NSAIDs | 47.4 | 38.6 | 41.3 | 37.5 | 43.4 | 46.9 |
Continuous variables are presented by mean ± SD. Categorical variables are presented as percentages. ACEI=angiotensin converting enzyme inhibitor, Ang1=angiopoietin-1, Ang2=angiopoietin-2, ARB=angiotensin receptor blocker, BNP=brain natriuretic peptide, BP=blood pressure, GFR=glomerular filtration rate, HS=high school, NSAID=non-steroidal anti-inflammatory drug, SD=standard deviation.