Table 2.

Multivariable linear regression estimating associations between Ang1, Ang2, and cardiac structure and function in the MESA-Angiogenesis cohort (N=1,358)

Parameter	Model	Ang1			Ang2
		Coefficient	(95% CI)	P-value	Coefficient	(95% CI)	P-value
RVEDM (g)	Unadjusted	0.0	(−0.2, 0.3)	0.77	−0.1	(−0.3, 0.1)	0.30
	Limited	0.0	(−0.2, 0.1)	0.88	0.0	(−0.2, 0.2)	0.96
	Full	0.0	(−0.2, 0.2)	0.97	0.0	(−0.2, 0.2)	0.80
RVEDV (ml)	Unadjusted	0.3	(−1.2, 1.8)	0.73	−0.9	(−2.4, 0.6)	0.23
	Limited	−0.3	(−1.2, 0.5)	0.46	−0.3	(−1.4, 0.9)	0.65
	Full	−0.3	(−1.1, 0.6)	0.58	0.1	(−1.0, 1.2)	0.87
RVSV (ml)	Unadjusted	0.0	(−1.0, 1.0)	0.97	−0.1	(−1.1, 1.0)	0.87
	Limited	−0.5	(−1.2, 0.2)	0.15	0.0	(−0.9, 0.9)	1.00
	Full	−0.4	(−1.1, 0.3)	0.24	0.3	(−0.5, 1.2)	0.46
RVEF (%)	Unadjusted	−0.2	(−0.5, 0.1)	0.29	0.4	(0.1, 0.8)	0.01
	Limited	−0.2	(−0.5, 0.1)	0.13	0.2	(−0.2, 0.5)	0.39
	Full	−0.2	(−0.5, 0.1)	0.19	0.2	(−0.1, 0.6)	0.18
LVEDM (g)	Unadjusted	0.0	(−1.5, 1.4)	0.96	1.2	(−0.5, 2.9)	0.16
	Limited	−0.2	(−1.2, 0.9)	0.77	0.7	(−0.6, 2.0)	0.29
	Full	−0.3	(−1.2, 0.6)	0.51	−0.1	(−1.4, 1.2)	0.85
LVEDV (ml)	Unadjusted	−0.2	(−1.7, 1.4)	0.84	0.6	(−0.8, 2.1)	0.40
	Limited	−0.6	(−1.7, 0.5)	0.31	1.0	(−0.2, 2.2)	0.10
	Full	−0.6	(−1.7, 0.5)	0.27	1.1	(−0.2, 2.3)	0.09

All results presented per standard deviation increase in Ang1 (1.67 ng/ml) or Ang2 (2.59 ng/ml). Limited model: adjusted for age, gender, race/ethnicity, height, weight, and study site. Full model: limited model + adjusted for education level, hypertension, systolic blood pressure, smoking status, pack-years smoking history, diabetes, total cholesterol. Ang1=angiopoietin-1, Ang2=angiopoietin-2, CI=confidence interval, EDM=end-diastolic mass, EDV=end-diastolic volume, EF=ejection fraction, LV=left ventricle, RV=right ventricle, SV=stroke volume. Coefficients, confidence intervals, and P values are bold where statistically significant.