Table 3.
Hazard of Incident Heart Failure or Cardiovascular Death per Standard Deviation Increase in Angl or Ang2 (MESA Case Cohort) (N= 1512)
| Model | HR | (95% Cl) | P Value |
|---|---|---|---|
| Angl | |||
| Unadjusted | 1.02 | (0.78–1.34) | .88 |
| Limited | 1.03 | (0.84–1.28) | .76 |
| Full | 1.00 | (0.78–1.28) | .996 |
| GFR | 1.00 | (0.79–1.27) | .98 |
| BNP* | 1.02 | (0.78–1.34) | .88 |
| Medic ations | 1.00 | (0.78–1.28) | 1.00 |
| Ang2 | |||
| Unadjusted | 1.37 | (1.27–1.47) | <.001 |
| Limited | 1.27 | (1.19–1J7) | <.001 |
| Full | 1.21 | (1.10—133) | <.001 |
| GFR | 1.23 | (1.11–137) | <.001 |
| BNP* | 1.03 | (0.82–1.28) | .81 |
| Medications | 1.22 | (1.10—135) | <.001 |
All results presented per standard deviation increase in Angl (1.96 ng/ mL> or Ang2 (2.95 ng/mL). The limited model is adjusted for age. sex. race/ethnicity, height, weight, and study site. The full model encompasses the limited model and is adjusted for education level, hypertension, systolic blood pressure, smoking status, pack-years smoking history, diabetes, and total cholesterol. Medication models were adjusted for use of bcta- blockcrs, angiotensin convening enzyme inhibitors, angiotensin receptor blockers, and nonsteroidal anti-inilammatoty drugs.
Coefficients, confidence intervals, and P values arc bold where statistically significant.
For models including BNP, N= 1257 owing to missing data.