Table 4.
Multivariable linear regression models estimating associations between Ang1, Ang2 and hemodynamic measurements in pulmonary arterial hypertension (N=73) and left heart disease (N=56) cohorts
| Model | PAH Cohort | LHD Cohort | |||||
|---|---|---|---|---|---|---|---|
| Coefficient | (95% CI) | P-value | Coefficient | (95% CI) | P-value | ||
| Ang1 | |||||||
| RAP | Unadjusted | −0.7 | (−2.0, 0.7) | 0.34 | - | - | - |
| (mmHg) | Adjusted | −0.5 | (−2.0, 0.9) | 0.45 | - | - | - |
| mPAP | Unadjusted | −2.8 | (−5.7, 0.1) | 0.06 | - | - | - |
| (mmHg) | Adjusted | −2.6 | (−5.6, 0.4) | 0.09 | - | - | - |
| PAWP | Unadjusted | −0.7 | (−1.8, 0.4) | 0.21 | - | - | - |
| (mmHg) | Adjusted | −0.8 | (−1.9, 0.3) | 0.16 | - | - | - |
| PVR | Unadjusted | −0.8 | (−1.9, 0.3) | 0.17 | - | - | - |
| (Wood units) | Adjusted | −0.8 | (−2.0, 0.3) | 0.15 | - | - | - |
| Cardiac Index | Unadjusted | 0.1 | (0.0, 0.3) | 0.15 | - | - | - |
| (L/min/m2) | Adjusted | 0.2 | (0.0, 0.3) | 0.07 | - | - | - |
| SBP | Unadjusted | 4.8 | (1.1, 8.4) | 0.01 | - | - | - |
| (mmHg) | Adjusted | 5.5 | (1.8, 9.2) | 0.004 | - | - | - |
| Ang2 | |||||||
| RAP | Unadjusted | 1.3 | (0.0, 2.7) | 0.05 | 3.0 | (2.0, 4.0) | <0.001 |
| (mmHg) | Adjusted | 1.8 | (0.5, 3.2) | 0.009 | 2.7 | (1.7, 3.8) | <0.001 |
| mPAP | Unadjusted | 0.8 | (−2.1, 3.8) | 0.57 | 3.6 | (0.5, 6.6) | 0.02 |
| (mmHg) | Adjusted | 1.4 | (−1.7, 4.4) | 0.37 | 2.8 | (−0.2, 5.8) | 0.07 |
| PAWP | Unadjusted | 0.3 | (−0.8, 1.4) | 0.61 | 3.5 | (1.8, 5.2) | <0.001 |
| (mmHg) | Adjusted | 0.8 | (−0.4, 1.9) | 0.18 | 3.4 | (1.6, 5.3) | 0.001 |
| PVR | Unadjusted | 0.6 | (−0.5, 1.7) | 0.27 | 0.2 | (−0.1, 0.6) | 0.23 |
| (Wood units) | Adjusted | 0.6 | (−0.6, 1.8) | 0.30 | 0.1 | (−0.2, 0.5) | 0.41 |
| Cardiac Index | Unadjusted | −0.1 | (−0.3, 0.1) | 0.20 | −0.2 | (−0.4, 0.1) | 0.18 |
| (L/min/m2) | Adjusted | −0.1 | (−0.3, 0.0) | 0.11 | −0.2 | (−0.4, 0.0) | 0.10 |
| SBP | Unadjusted | −4.3 | (−8.0, −0.7) | 0.02 | −2.0 | (−7.9, 3.9) | 0.50 |
| (mmHg) | Adjusted | −3.7 | (−7.5, 0.2) | 0.06 | −1.8 | (−7.9, 4.4) | 0.56 |
All results presented per standard deviation increase in Ang1 (PAH 2.65 ng/ml) or Ang2 (PAH 12.68 ng/ml, LHD 19.58 ng/ml). Adjusted model: adjusted for age, gender, race/ethnicity, and etiology of pulmonary hypertension (PAH cohort) or heart failure (LHD cohort). Ang1=angiopoietin-1, Ang2=angiopoietin-2, CI=confidence interval, LHD=left heart disease, mPAP=mean pulmonary artery pressure, PAH=pulmonary arterial hypertension, PAWP=pulmonary artery wedge pressure, PVR=pulmonary vascular resistance, RAP=right atrial pressure, SBP=systolic blood pressure.
Coefficients, confidence intervals, and P values are bold where statistically significant.