A. Localization of LZTFL1 in isolated germ cells was examined by immunofluorescence staining. LZTFL1 signal was observed in the cytoplasm of spermatocytes (panel a, arrows) and round spermatids (panels a and b, dotted arrows). Some signal appears near the manchette of elongating spermatids (panel b, arrow head), and is also localized in the developing sperm tails (panel c, star). No LZTFL1 signal was observed in the tails of the developed sperm (panel d). Images were taken with a confocal microscope.
B. LZTFL1 is not expressed in the epididymal sperm. Epididymal sperm were collected from cauda epididymis, and Western blot was conducted. LZTFL1 protein was detected in the testis, but not in sperm.