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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Metabolism. 2021 Jun 19;121:154819. doi: 10.1016/j.metabol.2021.154819

Figure 3. Metabolic roles of α-klotho in the brain.

Figure 3.

(A) α-Klotho may upregulate TRX protein activity by inhibiting TXNIP. (B) α-Klotho regulates hypothalamic neuron activity and gene expression via FGFR→AKT signaling. (C) α-Klotho may regulate calcium flux and subsequent membrane potential via TRPV channels. (D) α-Klotho activates STAT3 signaling via un unidentified receptor. TXNIP = thioredoxin interacting protein; TRX = thioredoxin; FGFR = fibroblast growth factor receptor; AKT = protein kinase B; ERK = extracellular-regulated kinase; FOXO1 = forkhead box 01; TRPV = transient receptor potential cation channel subfamily V; STAT3 = signal transducer and activator of transcription 3. Created with BioRender.com.