Chromatin protection assays. Left, protection of a regularly chromatinized DNA template and the expected DNA products. Right, protection of a dynamically chromatinized DNA template in which the residency time of the core nucleosome approaches that of the linker histones. Middle, resolution of the protected DNA fragments expected from each chromatin type. Blue, DNA; orange, core nucleosome; green, linker histone H1 (shades as in Fig. 1); Black arrows, cleavage sites; Blue rectangles, protected DNA fragments sizes, as resolved by agarose gel electrophoresis.