Figure 6:

Paraquat-induced apical-turn hair cell lesions are similar in Sirt3 heterozygous (Het,), homozygous (Homo,) and Sirt3 wild type (WT) mice. Mean cochleograms showing percent OHC loss and percent IHC loss as a function of percent distance from apex of the cochlea of Sirt3 WT, Het and Homo mice. Mean (+/− SEM) cochleograms from Control cochlea (0 μM paraquat) exhibit little OHC (A) or IHC (B) loss in Sirt3 WT (n=4), Het (n=4) and Homo (n=4) mice. Mean (n=6/group, +/− SEM) cochleograms showing (C) OHC loss and (D) IHC loss in Sirt3 WT, Het and Homo mice.