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. 2021 Jul 13;11:14385. doi: 10.1038/s41598-021-93755-y

Figure 6.

Figure 6

Impact of GPR55 deficiency on LV hypertrophy following MI. (a) Study design to assess the role of GPR55 in early hypertrophy and long-term remodelling. GPR55−/− and WT mice were randomly assigned to MI or sham surgery for 1 day or 28 days. (b) LV expression of foetal genes and Myh7 expression relative to the adult MHC isoform Myh6 in WT and GPR55−/− mice 1 day post-MI, as fold over Sham WT. (c) Representative haematoxylin & eosin stained midventricular cross-sections from WT and GPR55−/− mice 28 days post-MI or sham surgery, respectively (× 40 magnification, scale bar 100 µm) and (d) quantification of cardiomyocyte cross sectional area and diameter. (e) Heart weight (HW) per se and normalized against tibia length (TL) in WT and GPR55−/− mice 28 days post-MI or sham surgery, respectively. Bars indicate mean ± SE (n = 6–11/group) (Two-way ANOVA with Sidak’s post hoc test).