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. 2021 Jul 14;10:143. doi: 10.1038/s41377-021-00580-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–b Two-photon imaging of patch clamp integrated with TFOE in a mouse brain slice targeting GAD2-tdTomato negative pyramidal neurons and GAD2-tdTomato positive inhibitory interneurons. The patch pipette is visualized using the cyan-green fluorescent dye Alexa Fluor 488 in the intracellular electrode solution. c, d Membrane voltage response in an excitatory pyramidal cell upon TFOE stimulation (5 ms) at a distance of ~5 µm (c) and ~10 µm (d). e, f Voltage response in an inhibitory interneuron upon TFOE stimulation at ~5 µm at the membrane voltages of −75 mV (e) and −40 mV (f). Laser: 11.4 mW, 1.7 kHz, 5 ms duration.