Table 4.
Disproportionality data analysis.
| N | IC (95% CI) | PRR (95% CI) | |
|---|---|---|---|
| Levofloxacin | |||
| Arthralgia | 4231 | 1.75 (1.71–1.80) | 3.41 (3.31–3.51) |
| Pain in extremity | 2865 | 1.52 (1.47–1.58) | 2.90 (2.79–3.00) |
| Tendonitis | 4742 | 6.09 (6.06–6.13) | 96.65 (93.50–99.80) |
| Tendon pain | 1847 | 6.29 (6.22–6.36) | 120.88 (114.32–127.43) |
| Myalgia | 2373 | 1.23 (1.17–1.28) | 2.35 (2.26–2.44) |
| Tendon disconfort | 137 | 5.74 (5.49–5.99) | 91.45 (75.07–107.83) |
| Tendon disorder | 1995 | 6.27 (6.20–6.34) | 117.35 (111.25–123.45)130 |
| Ciprofloxacin | |||
| Arthralgia | 3504 | 1.26 (1.22–1.31) | 2.42 (2.34–2.50) |
| Tendonitis | 2714 | 5.07 (5.01–5.12) | 40.38 (38.77–41.99) |
| Pain in extremity | 2054 | 0.82 (0.76–0.89) | 1.78 (1.70–1.85) |
| Myalgia | 2021 | 0.78 (0.71–0.84) | 1.72 (1.65–1.79) |
| Muscular weakness | 880 | 0.97 (0.87–1.06) | 1.96 (1.84–2.09) |
| Tendon discomfort | 130 | 5.48 (5.23–5.73) | 73.09 (59.80–86.38) |
| Tendon disorder | 920 | 4.94 (4.84–5.04) | 36.59 (34.12–39.06) |
| Tendon pain | 1475 | 5.75 (5.68–5.82) | 75.11 (70.77–79.45) |
| Moxifloxacin | |||
| Arthralgia | 865 | 0.70 (0.61–0.80) | 1.63 (1.53–1.74) |
| Tendonitis | 514 | 4.11 (3.99–4.24) | 18.14 (16.62–19.66) |
| Tendon disorder | 195 | 4.12 (3.91–4.33) | 18.71 (16.23–21.19) |
| Myalgia | 569 | 0.41 (0.29–0.53) | 1.33 (1.22–1.43) |
| Tendon pain | 285 | 4.8 (4.63–4.97) | 30.75 (27.31–34.20) |
| Tendon discomfort | 13 | 3.29 (2.40–4.18) | 15.19 (8.75–21.63) |
| Ofloxacin | |||
| Arthralgia | 521 | 0.60 (0.48–0.73) | 1.52 (1.40–1.64) |
| Tendonitis | 674 | 5.12 (5.01–5.23) | 37.23 (34.51–39.96) |
| Tendon disorder | 260 | 5.13 (4.95–5.31) | 39.09 (34.54–43.63) |
| Myalgia | 422 | 0.61 (0.46–0.75) | 1.52 (1.39–1.66) |
| Tendon pain | 113 | 4.06 (3.78–4.34) | 18.28 (15.18–21.38) |
| Tendon discomfort | 12 | 3.55 (2.62–4.48) | 21.67 (12.22–31.12) |
| Norfloxacin | |||
| Tendonitis | 369 | 5.04 (4.89–5.19) | 35.18 (31.78–38.59) |
| Arthralgia | 235 | 0.27 (0.08–0.46) | 1.21 (1.06–1.35) |
| Myalgia | 209 | 0.41 (0.20–0.61) | 1.33 (1.16–1.49) |
| Tendon disorder | 54 | 3.61 (3.20–4.03) | 13.79 (10.55–17.02) |
| Tendon pain | 55 | 3.76 (3.36–4.17) | 15.49 (11.88–19.09) |
| Tendon discomfort | 11 | 3.81 (2.83–4.79) | 34.89 (19.20–50.58) |
Bolded text represents IC025 and PRR025, the lower ends of the 95% respective confidence intervals.
CI confidence interval; IC information component; N number of reports; PRR proportional reporting ratio.