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. 2021 Jul 13;11:14386. doi: 10.1038/s41598-021-93845-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential mRNA expression of genes upregulated in human ASM and mouse ASM samples. The fold change for mRNA was evaluated in both groups. The genes were validated in human ASM samples collected from non-asthmatic (NA) and asthmatic (Asth) patients (N = 5 in each group) and mouse ASM samples collected with and without mixed allergen (MA) exposure (N = 3 in each group). Data represented as mean ± SEM in each group. *p-value < 0.05, **p-value < 0.001. The statistical analysis and the graphs were constructed using GraphPad Prism 9.0.0 (GraphPad, San Diego, CA) (https://www.graphpad.com/scientific-software/prism/).