Table 2.
Between-treatment comparisons for change in Schiff sensitivity score and tactile threshold (intent-to-treat population).
| Test* | Control* | Test vs Cont** | |||
|---|---|---|---|---|---|
| Schiff sensitivity score | |||||
| Study 1 | BL | 2.70 (0.051) | 2.74 (0.051) | ||
| 7 d | −0.74 (−0.84, −0.65) −27.4% p < 0.0001 | −0.03 (−0.13, 0.06) −1.1% p = 0.5059 | −0.71 (−0.85, −0.57) −26.4% p < 0.0001 | ||
| 14 d | −1.39 (−1.54, −1.23) −51.1% p < 0.0001 | −0.10 (−0.25, 0.06) −3.6% p = 0.2276 | −1.29 (−1.51, 1.07) −49.2% p < 0.0001 | ||
| Study 2 | BL | 2.80 (0.039) | 2.83 (0.037) | ||
| 7 d | −0.49 (−0.67, −0.30) −17.5% p < 0.0001 | −0.54 (−0.73, −0.62) −19.4% p < 0.0001 | 0.06 (−0.21, 0.32) 2.2% p = 0.67699 | ||
| 14 d | −1.01 (−1.27, −0.74) −36.1% p < 0.0001 | −0.89 (−1.15, −0.62) −31.4% p < 0.0001 | −0.12 (−0.50, 0.25) −6.2% p = 0.5191 | ||
| Tactile threshold | |||||
| Study 1 | BL | 11.83 (0.378) | 11.50 (0.358) | ||
| 7 d | +6.00 (4.88, 7.13) 50.0% p < 0.0001 | +0.77 (−0.36, 1.90) 7.5% p = 0.1807 | 5.23 (3.63, 6.83) 42.0% p < 0.0001 | ||
| 14 d | +15.30 (13.34, 17.26) 128.6% p < 0.0001 | +0.77 (−1.20, 2.74) 7.5% p = 0.4428 | 14.53 (11.75, 17.31) 116.8% p < 0.0001 | ||
| Study 2 | BL | 11.50 (0.327) | 12.03 (0.362) | ||
| 7 d | +11.35 (6.91, 15.79) 97.5% p < 0.0001 | +10.15 (5.68, 14.63) 85.5% p < 0.0001 | 1.19 (−5.12, 7.51) 5.5% p = 0.7093 | ||
| 14 d | +18.58 (13.00, 24.15) 159.0% p < 0.0001 | +18.56 (12.98, 24.13) 156.7% p < 0.0001 | 0.02 (−7.89, 7.92) 0.1% p = 0.9962 | ||
Baseline values are raw means, all other are adjusted means from ANCOVA model.
BL Baseline, d day.
*Change from baseline (95% confidence interval), percentage change, p value. Percentage change calculated as 100*[(Treatment–BL)/BL].
**Difference (95% confidence interval), percentage change, p value: first-named minus second-named group such that, for Schiff sensitivity score, a negative difference favours the first-named group or, for tactile threshold, a positive difference favours the first-named group. Percentage change calculated as: 100*[(overall mean BL value + Test adjusted change from baseline)−(overall mean BL value + Control adjusted change from baseline)/(overall mean BL value + Control adjusted change from baseline)].