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. 2021 Jul 13;11:14396. doi: 10.1038/s41598-021-93831-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The expansion of CD45⁻ CD71⁺ GPA⁺ erythroid cells in peripheral blood mononuclear cells derived from patients with pediatric inflammatory diseases. (a) The percentage and absolute number of CD45⁻ CD71⁺ GPA⁺ erythroid cells in peripheral blood mononuclear cells among healthy control and patients with oligo/polyarticular JIA, KD, and SoJIA. (b) Gene expression of AHSP, HBD, and CA1 in whole peripheral blood mononuclear cells, CD45⁺ lymphocytes and monocytes, and CD71⁺ erythroid cells. The CD45⁺ lymphocytes and monocytes and the CD71⁺ erythroid cells are selectively extracted from fresh peripheral blood mononuclear cells derived from SoJIA patients using a cell sorter. The line indicates the average. Data are analyzed by the Mann–Whitney U test with Bonferroni correction. *P < 0.05; **P < 0.01; ***P < 0.001. oligo/poly JIA oligo/polyarticular juvenile idiopathic arthritis, KD Kawasaki disease, SoJIA systemic-onset juvenile idiopathic arthritis.