Table 1.
Clinical variables at the sample collection for the detection of PBCECs using flow cytometry.
| 1. Oligo/poly JIA | 2. Kawasaki disease | 3. Systemic-onset JIA | P value | |||
|---|---|---|---|---|---|---|
| 1 vs. 2 | 1 vs. 3 | 2 vs. 3 | ||||
| Number of patients | 11 | 21 | 12 | |||
| Age (years) | 8, 2–16 | 3, 0.3–9 | 7, 2–13 | 0.009 | 0.27 | 0.09 |
| Male :female | 5:6 | 13:8 | 5:7 | |||
| Laboratory data | ||||||
| White blood cells (109/L) | 7.1, 5.3–9.4 | 11.9, 2.9–20.8 | 26.7, 7.2–33.8 | 0.01 | 0.004 | 0.14 |
| Hemoglobin (g/dL) | 12.6, 10.9–14.6 | 11.2, 8.7–13.5 | 11.8, 8.4–14.9 | 0.14 | 0.36 | 1.0 |
| Red cell distribution width (%) | 12.8, 11.6–15.3 | 12.6, 11.8–13.8 | 14.5, 11.6–16.2 | 1.0 | 0.06 | 0.01 |
| Reticulocyteb (/μL) | 0.07, 0.06–0.11 | 0.05, 0.04–0.09 | 0.07, 0.03–0.13 | 0.07 | 1.0 | 1.0 |
| C-reactive protein (mg/dL) | 0.3, 0.02–3.7 | 5.4, 2.2–9.5 | 10.2, 0.02–36.0 | < 0.001 | 0.01 | 0.37 |
| Ferritin (ng/mL) | 34, 4–127 | 105, 44–1,101 | 333, 60–12,662 | 0.002 | 0.002 | 0.046 |
| Erythropoietinc (mIU/mL) | 4, 2–36 | 20, 0–30 | 38, 13–123 | 1.0 | 0.65 | 0.47 |
| Hepcidinc (pg/mL) | 31, 0–57 | 239, 99–501 | 574, 283–630 | 0.006 | < 0.001 | 0.009 |
| IL-6a (103 pg/mL) | 0, 0–0 | 24, 0–112 | 53, 0–1098 | 0.002 | 0.002 | 0.74 |
| IL-18a (ng/mL) | 46, 13–292 | 188, 44–697 | 3143, 396–21,140 | 0.008 | < 0.001 | < 0.001 |
| IL-18BPa (pg/mL) | 686, 594–866 | 1310, 647–9236 | 1950, 667–3427 | 0.14 | 0.28 | 1.0 |
| sTNFR1a (mIU/mL) | 267, 15–314 | 404, 86–885 | 675, 194–1213 | 0.06 | < 0.001 | 0.03 |
| sTNFR2a (pg/mL) | 3033, 1830–3606 | 7371, 3201–12,688 | 7113, 3041–14,951 | 0.001 | 0.002 | 1.0 |
| IFN-γa (ng/mL) | 19, 0–40 | 24, 0–262 | 10, 0–69 | 1.0 | 1.0 | 0.22 |
| G-CSFa (mIU/mL) | 13, 0–28 | 23, 0–62 | 15, 0–209 | 1.0 | 0.60 | 1.0 |
| GM-CSFa (pg/mL) | 6, 0–14 | 6, 0–11 | 4, 0–11 | 1.0 | 0.67 | 0.52 |
| Galectin-3a (ng/mL) | 25, 9–34 | 35, 12–85 | 67, 21–186 | 0.22 | 0.008 | 0.03 |
| Duration of feverd (days) | – | 5.5, 1–11 | 7, 2–22 | – | – | 0.55 |
Data are shown as the number and percentage or median and range. Bonferroni adjustment was used for multiple comparisons. Comparative analyses were performed among patients with data available. Patients with oligo/polyarticular JIA vs. Kawasaki disease vs. systemic-onset JIA.
JIA juvenile idiopathic arthritis, IL-18BP Interleukin-18 binding protein, sTNFR soluble tumor necrosis factor receptor, IFN-γ interferon-gamma.
a10 vs. 14 vs. 9.
b9 vs. 13 vs. 7.
c3 vs. 7 vs. 5.
d0 vs. 21 vs. 12.