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. 2021 Jul 13;11:14381. doi: 10.1038/s41598-021-93849-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of graph-theoretic analyses and correlation analysis. (A) By setting the values of graph measures at baseline to 1.0 (shown as a line at the value of 1.0), the relative ratio of global graph measures after coffee consumption are presented. (B) Changes after coffee consumption in the nodal measures of graph-theoretic analyses are presented (FDR-corrected P < 0.05). Larger nodes indicate greater differences between the conditions. The regions showing higher significance of differences are colored red, whereas the regions showing lower significance of difference are colored blue.