Table 2.
Correlation between imaging biomarkers in overall subjects and DLB patients.
| DAT-AP | DAT-PC | DAT-AC | PC1 | FDR-PP | FBB-SUVR | |
|---|---|---|---|---|---|---|
| Overall subjects | ||||||
| DAT-PP | ||||||
| Rho (p value) | 0.93 (< 0.001) | 0.76 (< 0.001) | 0.83 (< 0.001) | − 0.52 (< 0.001) | − 0.85 (< 0.001) | − 0.14 (0.174) |
| VIF | 7.18 | 2.40 | 3.24 | 1.37 | 3.51 | 1.02 |
| DAT-AP | ||||||
| Rho (p value) | 0.80 (< 0.001) | 0.92 (< 0.001) | − 0.54 (< 0.001) | − 0.80 (< 0.001) | − 0.14 (0.180) | |
| VIF | 2.78 | 6.28 | 1.41 | 2.77 | 1.02 | |
| DAT-PC | ||||||
| Rho (p value) | 0.94 (< 0.001) | − 0.65 (< 0.001) | − 0.62 (< 0.001) | − 0.18 (0.082) | ||
| VIF | 8.49 | 1.75 | 1.63 | 1.03 | ||
| DAT-AC | ||||||
| Rho (p value) | − 0.67 (< 0.001) | − 0.71 (< 0.001) | − 0.21 (0.045) | |||
| VIF | 1.82 | 1.99 | 1.04 | |||
| PC1 | ||||||
| Rho (p value) | 0.51 (< 0.001) | 0.44 (< 0.001) | ||||
| VIF | 1.35 | 1.24 | ||||
| FDR-PP | ||||||
| Rho (p value) | 0.16 (0.135) | |||||
| VIF | 1.02 | |||||
| DLB patients | ||||||
| DAT-PP | ||||||
| Rho (p value) | 0.90 (< 0.001) | 0.61 (< 0.001) | 0.72 (< 0.001) | − 0.28 (0.042) | − 0.86 (< 0.001) | 0.10 (0.477) |
| VIF | 5.18 | 1.58 | 2.10 | 1.08 | 3.83 | 1.01 |
| DAT-AP | ||||||
| Rho (p value) | 0.72 (< 0.001) | 0.89 (< 0.001) | − 0.43 (0.001) | − 0.80 (< 0.001) | 0.07 (0.601) | |
| VIF | 2.08 | 4.89 | 1.22 | 2.82 | 1.01 | |
| DAT-PC | ||||||
| Rho (p value) | 0.91 (< 0.001) | − 0.40 (0.003) | − 0.50 (< 0.001) | 0.11 (0.424) | ||
| VIF | 5.82 | 1.19 | 1.33 | 1.01 | ||
| DAT-AC | ||||||
| Rho (p value) | − 0.51 (< 0.001) | − 0.63 (< 0.001) | 0.06 (0.656) | |||
| VIF | 1.34 | 1.65 | 1.00 | |||
| PC1 | ||||||
| Rho (p value) | 0.20 (0.150) | 0.18 (0.199) | ||||
| VIF | 1.04 | 1.04 | ||||
| FDR-PP | ||||||
| Rho (p value) | − 0.09 (0.510) | |||||
| VIF | 1.01 | |||||
Rho and p values are results of Pearson’s correlation analyses.
DAT dopamine transporter, DAT-AP DAT uptake in the anterior putamen, DAT-AC DAT uptake in the anterior caudate, DAT-PC DAT uptake in the posterior caudate, DAT-PP DAT uptake in the posterior putamen, FBB-SUVR 18F-Florbetaben standardized uptake value ratio, FDG 18F-fluorodeoxyglucose uptake, FDR-PP FDG to DAT ratio in the posterior putamen, PC1 the first principal component of FDG subject residual profile, VIF variance inflation factor.