Table 5.
Predictors for neuropsychological test scores in DLB patients.
| Predictor | Attention | Language | Visuospatial | Memory | Frontal/executive | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | ||
| Univariate | DAT-PP | 0.17 (0.11) | 0.139 | 0.37 (0.15) | 0.019 | 0.35 (0.34) | 0.306 | 0.23 (0.08) | 0.009 | 0.25 (0.10) | 0.014 |
| DAT-AP | 0.16 (0.10) | 0.120 | 0.40 (0.14) | 0.006 | 0.31 (0.32) | 0.347 | 0.21 (0.08) | 0.009 | 0.21 (0.09) | 0.030 | |
| DAT-PC | 0.43 (0.20) | 0.042 | 0.85 (0.27) | 0.003 | 0.77 (0.64) | 0.235 | 0.48 (0.15) | 0.002 | 0.54 (0.16) | 0.002 | |
| DAT-AC | 0.29 (0.13) | 0.037 | 0.62 (0.17) | 0.001 | 0.55 (0.42) | 0.198 | 0.33 (0.10) | 0.001 | 0.37 (0.11) | 0.002 | |
| FDR-PP | − 1.33 (1.26) | 0.298 | − 3.44 (1.72) | 0.053 | − 3.21 (3.80) | 0.402 | − 1.75 (0.95) | 0.073 | − 1.88 (1.08) | 0.091 | |
| PC1 | − 0.01 (0.004) | 0.014 | − 0.02 (0.005) | 0.004 | − 0.03 (0.01) | 0.005 | − 0.01 (0.003) | 0.001 | − 0.01 (0.003) | < 0.001 | |
| FBB-SUVR | 0.31 (0.43) | 0.480 | − 0.07 (0.61) | 0.914 | 1.91 (1.27) | 0.140 | − 0.10 (0.34) | 0.775 | 0.15 (0.37) | 0.679 | |
| Multivariate |
DAT-PP DAT-PC |
0.13 (0.19) 0.69 (0.36) |
0.487 0.062 |
0.11 (0.10) 0.36 (0.19) |
0.302 0.069 |
0.10 (0.12) 0.43 (0.21) |
0.375 0.047 |
||||
|
DAT-PP PC1 |
0.30 (0.14) − 0.01 (0.005) |
0.042 0.010 |
0.18 (0.08) − 0.01 (0.003) |
0.022 0.002 |
0.18 (0.08) − 0.01 (0.003) |
0.035 < 0.001 |
|||||
|
DAT-AP PC1 |
0.31 (0.14) − 0.01 (0.005) |
0.029 0.021 |
0.15 (0.07) − 0.01 (0.003) |
0.051 0.005 |
0.10 (0.08) − 0.01 (0.003) |
0.239 < 0.001 |
|||||
|
DAT-PC PC1 |
0.33 (0.20) − 0.01 (0.004) |
0.109 0.036 |
0.69 (0.26) − 0.01 (0.005) |
0.011 0.015 |
0.38 (0.14) − 0.01 (0.003) |
0.008 0.003 |
0.39 (0.14) − 0.01 (0.003) |
0.009 < 0.001 |
|||
|
DAT-AC PC1 |
0.20 (0.14) − 0.01 (0.004) |
0.158 0.057 |
0.49 (0.18) − 0.01 (0.005) |
0.008 0.039 |
0.24 (0.10) − 0.01 (0.003) |
0.015 0.009 |
0.23 (0.10) − 0.01 (0.003) |
0.036 0.001 |
|||
Results are based on general linear models for neuropsychological z scores after controlling for age, sex, education, HTN, DM, DWMH, and PWMH. The model emphasized in bold reflects minimizing AICs.
AIC akaike information criterion, DAT dopamine transporter, DAT-AC DAT uptake in the anterior caudate, DAT-AP DAT uptake in the anterior putamen, DAT-PC DAT uptake in the posterior caudate, DAT-PP DAT uptake in the posterior putamen, DLB dementia with Lewy bodies, DM diabetes mellitus, DWMH deep white matter hyperintensities, FBB-SUVR 18F-Florbetaben standardized uptake value ratio, FDG 18F-fluorodeoxyglucose uptake, FDR-PP FDG to DAT ratio in the posterior putamen, HTN hypertension, PC1 the first principal component of FDG subject residual profile, PWMH periventricular WMH.