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. 2021 Jun 30;12:698133. doi: 10.3389/fphar.2021.698133

FIGURE 1.

FIGURE 1

Time-dependent increase in expression of MBP, CNPase, Tyro3, Axl and Mertk mRNAs in PEALut-treated OPCs. PEALut time-dependently increases expression of MBP, CNPase and Tyro3 in differentiating OPCs, while it induces a reduction of Axl and Mertk mRNAs. Cultures of OPCs were treated on the plating day (DIV 1) with 10 μM PEALut and processed at DIV 2, 4, and 8 for real-time PCR. Data from two separated experiments (6 values) are expressed as fold-increase with respect to the control (vehicle) at DIV 2 and are means ± SEM. Data were analyzed with two-way ANOVA followed by post hoc Holm-Sidak’s multiple comparison test. MBP: *p < 0.05 vs Vehicle; ****p < 0.0001 vs Vehicle. CNPase: **p < 0.005 vs Vehicle; ***p < 0.001 vs Vehicle; Tyro3: *p < 0.05 vs Vehicle; ****p < 0.0001 vs Vehicle; °°°°p < 0.0001 vs PEALut 4 days old culture. Axl and Mertk: *p < 0.05 vs Vehicle.