FIGURE 2.

PEALut effects on rapamycin-treated OPCs at DIV 8. Cultures of OPCs were treated with 10 μM PEALut at DIV 2 and processed at DIV 8 for real-time PCR. Rapamycin was added 30 min before PEALut. Data are expressed as mean ± SEM. Data were analyzed with one-way ANOVA followed by post hoc Holm-Sidak’s multiple comparisons test. Data were obtained from five separated experiments (15 values). MBP: **p < 0.005 vs vehicle; °°p < 0.005 vs rapamycin; ••p < 0.005 vs PEALut. CNPase: **p < 0.01 vs vehicle; ****p < 0.0001 vs vehicle; °°°°p < 0.0001 vs rapamycin; Tyro3: ****p < 0.0001 vs vehicle; °°°°p < 0.0001 vs rapamycin; •••p < 0.001 vs PEALut.