FIGURE 4.

PEALut reversed the rapamycin-induced increases in Axl and Mertk mRNA in OPCs at DIV 8. Cultures of OPCs were treated with 10 μM PEALut at DIV 2 in cultures and processed at DIV 8 for real-time PCR. Rapamycin was added 30 min before PEALut. Data are expressed as mean ± SEM. Data were analyzed with one-way ANOVA followed by post hoc Holm-Sidak’s multiple comparison test. Data were obtained from four separated experiments (12 values) Axl: **p< 0.005 vs Vehicle; °°°°p< 0.0001 vs Rapamycin. Mertk: *p< 0.05 vs Vehicle; ****p< 0.0001 vs Vehicle; °°°°p< 0.0001 vs Rapamycin.