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. 2021 Jun 30;12:705813. doi: 10.3389/fphar.2021.705813

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Copyright © 2021 Zhang, Meng, Chen, Chen, Huang, Zhang, Liang, Ding, Xue, Chen, Shi and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LF DBS of the SNr impaired the methamphetamine-induced CPP extinction and had no effect on methamphetamine-primed reinstatement. After methamphetamine conditioning (1 mg/kg), sham DBS or LF DBS (20 Hz, 150 μA, 100 μs) was delivered into the SNr during each of the drug-free extinction sessions (15 min). LF DBS significantly impaired the extinction sessions compared with the sham DBS. A priming injection of methamphetamine (1 mg/kg) was given to the sham DBS and LF DBS groups, and both groups of rats exhibited significant drug-seeking behaviors. Data are shown as mean ± SEM. **p < 0.01 (sham DBS) and ^### p < 0.0001 compared with baseline (LF DBS). Sham DBS: n = 7; LF DBS: n = 6.