TABLE 1.
Expression levels and functions of circMTO1 in different tumors.
| Tumor type | Expression level | Target miRNAs | Target proteins | Associated cellular process | Clinicopathological features | References |
| Cervical cancer | UP | miR-6893 | S100A1; Beclin1; p62 | Promotes cell proliferation, migration, invasion, and inhibits apoptosis | − | Chen M. et al., 2019 |
| Gallbladder cancer | UP | − | − | − | TNM stage, lymph node metastasis, distant metastasis, poorer progression-free survival, poorer overall survival, | Wang X. et al., 2020 |
| Rectal cancer | Down | miR-19b-3p | JAK1/STAT3; AMPK | Inhibits cell proliferation, migration, invasion, and induces apoptosis | − | Fan et al., 2019 |
| Osteosarcoma | Down | miR-630 | KLF6 | Inhibits cell proliferation, migration, invasion, and induces apoptosis | Enneking stage, poorer overall survival | Liu et al., 2021 |
| Glioblastoma | Down | miR-92, miR-630 | WWOX | Inhibits cell proliferation, induces apoptosis | Advanced clinical stage, poorer overall survival | Rao et al., 2018; Zhang X. et al., 2019 |
| Gastric carcinoma | Down | miR-3200-5p, miR-199a-3p | PEBP1; PAWR | Inhibits cell proliferation, migration, invasion, and induces apoptosis | Higher TNM stage, poorer overall survival | Hu et al., 2020; Song et al., 2020 |
| Lung adenocarcinoma | Down | miR-17 | QKI-5 | Inhibits cell proliferation | Lymph node metastasis, advanced clinical stage, poorer overall survival, poorer progression-free survival | Zhang B. et al., 2019 |
| Ovarian cancer | Down | miR-760, miR-182-5p | SOCS3; KLF15 | Inhibits cell proliferation, migration, invasion | Poorer overall survival | Li L. et al., 2020; Wang N. et al., 2020 |
| Hepatocellular carcinoma | Down | miR-9, miR-9-5p | p21; NOX4 | Inhibits cell proliferation, migration, invasion, and induces apoptosis | Poorer overall survival | Han et al., 2017; Wang J. et al., 2020 |
| Renal cell carcinoma | Down | miR9 miR223 | LMX1A | Inhibits cell proliferation, migration, invasion | Poorer overall survival | Li K. et al., 2020 |
| Prostate cancer | Down | miR-17-5p | − | Inhibits cell proliferation and invasion | Pathological T/N stage, poorer overall survival, poorer disease-free survival | Hu and Guo, 2020 |
| Bladder cancer | Down | miR-221 | E-cadherin/N-cadherin | Inhibits migration, invasion | Distant metastasis, poorer overall survival, poorer disease-free survival | Li Y. et al., 2019 |
| Colorectal cancer | Down | − | Wnt/β-catenin | Inhibits cell proliferation and invasion | TNM stage, lymph node metastasis, poorer overall survival | Ge et al., 2018 |
| Breast cancer | Down | − | TRAF4; Eg5 | Inhibits cell proliferation | Poorer overall survival | Liu et al., 2018 |