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Clinical manifestations of BAK toxicity.
| Pain/discomfort [45, 46] |
| Tearing [46] |
| Ocular surface staining [27, 46–48] |
| Increased tear break-up time [25, 27, 30, 46, 47, 49–51] |
| Lower Schirmer scores [46, 47] |
| Punctate keratitis [25, 26, 30] |
| Worse OSDI scores [27, 30, 48, 49, 52, 53] |
| Subconjunctival inflammation/fibrosis [9, 54–56] |
| Reduced success of glaucoma filtering surgery, [9, 57–59] |
| Increased risk of cataract surgery [60, 61] |
| Reduced quality of life [47, 52] |
