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. 2021 Jun 30;9:675998. doi: 10.3389/fcell.2021.675998

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Copyright © 2021 An, Wang, Jin, Zhou, Gao, Chen, Reinach, Liu, Xue and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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6C can effectively maintain the expression of primary mCEC related genes. (A) Immunofluorescence staining of mCEC function markers (green). Nuclei were stained with DAPI (blue). P63 and K14 are markers representing the characteristics of corneal epithelial stem cells. Pax6 is a key transcription factor regulating corneal epithelial cell fate. K12 is a marker of mCEC differentiation. (B) qRT-PCR analysis of P63, K14, Pax6 and K12 gene expression (normalized to ctrl). Data expressed as the means ± SEM from three separate experiments (*P < 0.05, **P < 0.01, ****P < 0.0001, ns: no significance). (C) 6C can promote the formation of clones of mCEC (red arrow).