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. 2021 Jun 30;12:689747. doi: 10.3389/fphys.2021.689747

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Copyright © 2021 Lagarde, Jeanson, Portais, Galinier, Ader, Casteilla and Carrière.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of lipolysis inhibition induced by adipocyte dependent lactate production in response to increased glucose utilization stimulated by insulin. Imported glucose following insulin signaling is converted to lactate and then exported. By an autocrine/paracrine action, lactate activates the GPR81 receptor which, through its effects on adenylate cyclase, decreases the level of cAMP and therefore lipolysis. Adapted from Ahmed et al. (2010). Pl3K, phosphoinositide 3-kinase; POE3B, phosphodiesterase 3B; AMPc, cyclic adenosine monophosphate; ATP, adenosine triphosphate; AC, adenylate cyclase; and GPR81, G protein-coupled receptors associated with inhibitory regulative G-protein (Gi).