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. 2021 Jun 13;25(14):6841–6854. doi: 10.1111/jcmm.16689

FIGURE 8.

FIGURE 8

SENP1 depletion promotes IH‐induced cognitive decline. (A–E) Cognitive function of mice with or without SENP1 knockdown under normoxia and IH conditions was analysed by Morris water maze (MWM) test. Mice swim in the pool for 60 seconds at day 6, and other days’ test termination time was subject to the climbing platform. (A) There was no difference among four experimental groups in average swimming speed throughout 6 consecutive days. (B) The swimming trail map of mouse in the swimming pool during 60 seconds at day 6. (C) Latency, the time that mice first climbed onto the hidden platform or first passed through the area where the platform was located. (D) The percentage of time that mice spent in the quadrant where the platform is located versus the total time. (E) The frequency of passing through the area where the platform is located. n = 12 per group. * P < .05, ** P < .01, *** P < .001 versus the normoxia groups. ### P < .001 versus the SENP1+/+ group under IH condition