FIGURE 1.

PLAC8 expression was associated with breast cancer outcome and ADM response. A, B. The correlation between PLAC8 expression levels with breast cancer subtype (B) and histological grade (C); C. Immunohistochemistry analysis of PLAC8 expression in normal breast and correspondent breast cancer tissues. Scale bar  =  50 µm; D. mRNA expression of PLAC8 between normal breast and breast cancer; E. Shown are representative images of PLAC8 staining using immunohistochemical staining for ADM resistance and ADM‐sensitive breast cancer, and PLAC8 expression was relatively increased in ADM resistance breast cancer case. F. The results from one independent GEO dataset (GSE24460) showed that PLAC8 expression was significantly up‐regulated in ADM‐resistant MCF‐7/ADMR cells compared with parental MCF‐7. Each bar represents the mean ± SD of three independent experiments. *P < .05, **P < .01, ***P < .001