TABLE 1.

This table summarizes the effects of SIRT2 on different cardiovascular states and shows the corresponding proteins that are currently known to interact with SIRT2

Disease	Known effects	Related molecule and Ref.
Pathological myocardial hypertrophy	Inhibition	LKB1, 26 tubulin, 27 FOXO3a, 9 FOXO1 and PGC1‐α, 28 NFATc2, 29 CSN6, 30 PHF19 31
Myocardial ischaemia‐reperfusion injury	Inhibition/Promotion	14‐3‐3 zeta, 38 BAD, 38 p53 39
Diabetic cardiomyopathy	Inhibition	α‐tubulin 45
Heart failure	Inhibition	BUBR1, 64 NFATc2 29
Atherosclerosis	Inhibition	MicroRNA‐140‐5p 81
Oxidative stress‐induced endothelial cell damage	Inhibition/Promotion (according to the degree of oxidative stress)	p53, 85 NF‐κB, 85 FOXO3a 86
Vascular remodelling	Regulation	α‐tubulin
Energy metabolism in endothelial cells	Maintain normal energy metabolism	PEPCK‐C, 15 FOXO1 97