FIGURE 4.
(A‐E) Effect of metformin on HUA‐induced/inhibited of phospho‐AMPK, phospho‐IRS1, phospho‐Akt and translocation of membrane GLUT4 in primary cardiomyocytes. (B) *P < .05 vs. Ins and Ins+HUA+Met; #P < .01 vs. Ins+HUA+Met. (C) *P < .05 vs. Ins+HUA and Ins+CC; #P < .01 vs. Ins+HUA+Met. (D) *P < .05 vs. Ins+HUA, Ins+Met and Ins+HUA+Met+CC. (E) *P < .05 vs. Ins and Ins+HUA+Met; #P < .01 vs. Ins+HUA. (F‐J) Effect of AICAR on HUA‐induced/inhibited of phospho‐AMPK, phospho‐IRS1, phospho‐Akt and translocation of membrane GLUT4 in primary cardiomyocytes. G, *P < .05 vs. Ins and Ins+HUA+Met; #P < .01 vs. Ins+HUA+Met. (H) *P < .05 vs. Ins+HUA and Ins+CC. (I) *P < .05 vs. Ins+HUA, Ins+Met and Ins+HUA+Met+CC. (J) *P < .05 vs. Ins and Ins+HUA+Met; #P < .01 vs. Ins+HUA