FIGURE 4.

Effect of vitamin E treatment on airway hyperresponsiveness and pulmonary inflammation with aging. Vitamin E decreased the AHR (A). The cell counts in BALF (B). Vitamin E decreased the level of Th2 cytokines (C) and ROS formation (D). Vitamin E restored the GSH level in serum and lung tissues (E) as well as the SOD level in serum (F). ^*** P < .001 at the respective weeks, between the positive asthma groups (young negative, old negative) vs. the treatment groups (young asthma, old asthma); ^### P < .001 between the treatment groups at 6 and 24 w. Data were normalized in order to compare between the effects of antioxidant treatment on the asthma mouse model