TABLE 1.
Clinicopathological characteristics of HCC patients from the TCGA database
| Clinicopathological variables | Total patients | Ferroptosis‐H | Ferroptosis‐L | P‐value |
|---|---|---|---|---|
| (n = 363) | (n = 151) | (n = 212) | ||
| Age (years) | .058 | |||
| <65 | 213 (58.8) | 97 (64.7) | 116 (54.7) | |
| ≥65 | 149 (41.2) | 53 (35.3) | 96 (45.3) | |
| Gender | .448 | |||
| Female | 117 (32.2) | 52 (34.4) | 65 (30.7) | |
| Male | 246 (67.8) | 99 (65.6) | 147 (69.3) | |
| T‐stage | .001 | |||
| T1 + T2 | 268 (74.2) | 98 (64.9) | 170 (81.0) | |
| T3 + T4 | 93 (25.8) | 53 (35.1) | 40 (19.0) | |
| N‐stage | .165 | |||
| N0 | 246 (68.0) | 108 (72.0) | 138 (65.1) | |
| N1 | 116 (32.0) | 42 (28.0) | 74 (34.9) | |
| M‐stage | .106 | |||
| M0 | 260 (71.6) | 115 (76.2) | 145 (68.4) | |
| M1 | 103 (28.4) | 36 (23.8) | 67 (31.6) | |
| AJCC stage | <.001 | |||
| I + II | 251 (74.0) | 88 (63.3) | 163 (81.5) | |
| III + IV | 88 (26.0) | 51 (36.7) | 37 (18.5) | |
| AFP (mg/ml) | .015 | |||
| <400 | 208 (76.5) | 72 (68.6) | 136 (81.4) | |
| ≥400 | 64 (23.5) | 33 (31.4) | 31 (18.6) | |
| Child‐Pugh grade | .208 | |||
| A | 213 (90.6) | 74 (87.1) | 139 (92.7) | |
| B | 21 (8.9) | 11 (12.9) | 10 (6.7) | |
| C | 1 (0.4) | 0 (0) | 1 (0.7) | |
| ECOG Performance status | .030 | |||
| 0 | 162 (57.0) | 53 (48.6) | 109 (62.3) | |
| 1 | 81 (28.5) | 33 (30.3) | 48 (27.4) | |
| 2 | 26 (9.2) | 13 (11.9) | 13 (7.4) | |
| 3 | 12 (4.2) | 7 (6.4) | 5 (2.9) | |
| 4 | 3 (1.1) | 3 (2.8) | 0 (0) | |
| Family history of cancer | .131 | |||
| NO | 204 (65.2) | 91 (70.0) | 113 (61.7) | |
| YES | 109 (34.8) | 39 (30.0) | 70 (38.3) | |
| Grade | <.001 | |||
| G1‐2 | 224 (62.6) | 72 (48.0) | 152 (73.1) | |
| G3‐4 | 134 (37.4) | 78 (52.0) | 56 (26.9) | |
| Alcohol consumption | .848 | |||
| NO | 248 (68.3) | 104 (68.9) | 144 (67.9) | |
| YES | 115 (31.7) | 47 (31.1) | 68 (32.1) | |
| Hepatitis B | .420 | |||
| NO | 266 (73.3) | 114 (75.5) | 152 (71.7) | |
| YES | 97 (26.7) | 37 (24.5) | 60 (28.3) | |
| Hepatitis C | .128 | |||
| NO | 310 (85.4) | 134 (88.7) | 176 (83.0) | |
| YES | 53 (14.6) | 17 (11.3) | 36 (17.0) | |
| Liver fibrosis Ishak score category | .067 | |||
| No fibrosis | 73 (34.4) | 21 (27.6) | 52 (38.2) | |
| Portal fibrosis | 31 (14.6) | 15 (19.7) | 16 (11.8) | |
| Fibrous speta | 28 (13.2) | 12 (15.8) | 16 (11.8) | |
| Nodular formation and incomplete cirrhosis | 9 (4.2) | 6 (7.9) | 3 (2.2) | |
| Established cirrhosis | 71 (33.5) | 22 (28.9) | 49 (36.0) | |
| Post‐operative radiotherapy | .089 | |||
| NO | 234 (98.3) | 80 (96.4) | 154 (99.4) | |
| YES | 4 (1.7) | 3 (3.6) | 1 (0.6) | |
| Surgical margin resection status | .048 | |||
| R0 | 319 (89.6) | 127 (85.8) | 192 (92.3) | |
| R1 | 37 (10.4) | 21 (14.2) | 16 (7.7) | |
| Vascular invasion | <.001 | |||
| None | 201 (65.5) | 63 (52.1) | 138 (74.2) | |
| Micro | 90 (29.3) | 47 (38.8) | 43 (23.1) | |
| Macro | 16 (5.2) | 11 (9.1) | 5 (2.7) |