TABLE 2.
Hub genes and top GO terms and KEEG pathways of enrichment analyses
| Category | Term | Count | P‐Value | Genes |
|---|---|---|---|---|
| BP | GO:0 006 955~immune response | 9 | 3.85E‐10 | CXCL10, CD74, HLA‐DRB5, CXCL9, CCL5, CCL4, CXCL13, HLA‐DRB1, HLA‐DQB1 |
| GO:0 070 098~chemokine‐mediated signalling pathway | 6 | 2.28E‐9 | CXCL10, CXCL9, CCL5, CCL4, CXCR4, CXCL13 | |
| GO:0 002 381~immunoglobulin production involved in immunoglobulin mediated immune response | 3 | 6.45E‐6 | HLA‐DRB5, HLA‐DRB1, HLA‐DQB1 | |
| CC | GO:0 009 897~external side of plasma membrane | 6 | 3.82E‐7 | CXCL10, CD74, HLA‐DRB5, CXCL9, CD69, HLA‐DRB1 |
| GO:0 042 613~MHC class II protein complex 4 | 4 | 5.51E‐7 | CD74, HLA‐DRB5, HLA‐DRB1, HLA‐DQB1 | |
| GO:0 071 556~integral component of lumenal side of endoplasmic reticulum membrane | 4 | 1.30E‐6 | CD74, HLA‐DRB5, HLA‐DRB1, HLA‐DQB1 | |
| MF | GO:0 008 009~chemokine activity | 5 | 6.14E‐8 | CXCL10, CXCL9, CCL5, CCL4, CXCL13 |
| GO:0 048 248~CXCR3 chemokine receptor binding | 3 | 6.38E‐6 | CXCL10, CXCL9, CXCL13 | |
| GO:0 031 730~CCR5 chemokine receptor binding | 3 | 1.78E‐5 | STAT1, CCL5, CCL4 | |
| KEGG | hsa04062:Chemokine signalling pathway | 7 | 2.91E‐7 | CXCL10, CXCL9, STAT1, CCL5, CCL4, CXCR4, CXCL13 |
| hsa04620:Toll‐like receptor signalling pathway | 5 | 2.40E‐5 | CXCL10, CXCL9, STAT1, CCL5, CCL4 | |
| hsa04060:Cytokine‐cytokine receptor interaction | 6 | 3.41E‐5 | CXCL10, CXCL9, CCL5, CCL4, CXCR4, CXCL13 |
Abbreviations: BP, biological process; CC, cellular component; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MF, molecular function.