FIGURE 2.

Up‐regulation of miR‐211‐5p within the CA1 region of CUMS rats ameliorates depression‐like behaviours. A, Construct of AAV‐miR‐211‐5p and experimental paradigm. B, Representative site of bilateral viral injections into the CA1 hippocampus. C, Validation of miR‐211‐5p overexpression efficiency in CA1 regions showed that the expression level of miR‐211‐5p was significantly increased in CUMS rats. Up‐regulation of miR‐211‐5p in CUMS rats (D) increased sucrose consumption and (E) decreased immobility times and increased swimming times. N = 6 per group. Data are presented as the means ± SEMs. *P < .05, **P < .01 vs. wild type; ^# P < .05, ^## P < .01 vs. AAV‐control (CUMS+AAV‐Ctrl). WT, wide type