FIGURE 4.

Knock‐down of miR‐211‐5p within the CA1 region of normal rats induced depression‐like behaviours. A, Schematics of AAV‐ miR‐211‐5p sponge and experimental paradigm. B, Illustration of viral injection site. C, Efficiency of miR‐211‐5p knock‐down within the CA1 region. Knock‐down of miR‐211‐5p in normal rats (D) decreased sucrose consumption and (E) increased immobility times and decreased swimming times. N = 6 per group. Data are presented as the means ± SEMs. **P < .01 vs. WT/AAV‐control (WT+AAV‐control). WT, wide type; Ctrl, control