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. 2021 Jul 14;18:20. doi: 10.1186/s12977-021-00564-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The complete nucleotide and deduced amino acid sequence of the XtERV-S proviral genome. The sequence is shown from the beginning of the 5′ U3 region to the end of the 3′ U5. The LTR sequence is in black italics and its inverse repeats are double underlined. The gag, pol and env ORFs are in red, blue and purple, respectively, and termination codons are marked by an asterisk. The Orf-x2 sequence is in light green. The positions of the functional motifs are bolded and highlighted and include the following in order: PBS (primer binding site); basic regions of Gag; MHR (major homology region); GQR motif; PSAP late domain; PR (protease); RT/RNH (reverse transcriptase/RNase H); CWIC (isomerase domain); furin site; ISD (immunosuppressive domain); MSD (membrane spanning domain); PPT (polypurine tract); polyA (polyadenylation signal). Arrows indicate the splice donor and acceptor sites. The dUTPase region of pol is underlined and bolded