Figure 1. Patients Who Were Opioid Naive and Who Subsequently Received an Opioid Prescription vs Linear Projections Based on Preguideline Trend.

The vertical blue line indicates the 2016 release of the Centers for Disease Control and Prevention’s “Guideline for Prescribing Opioids for Chronic Pain”¹⁰; orange line, projected opioid prescriptions based on linear projections from preguideline trend; shading, 95% CI; dark blue line, observed opioid prescriptions.