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. 2021 Jun 30;12:698677. doi: 10.3389/fimmu.2021.698677

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Copyright © 2021 Lin and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Seven identified HLA-G isoforms generated from its primary transcript alternative splicing. (A) The heavy chain of membrane-bound isoforms HLA-G1, -G2, -G3, -G4 generated by an mRNA containing a stop codon in exon 6. (B) Soluble isoforms HLA-G5 and HLA-G6 generated by an mRNA with a pre-stop codon in intron 4, which terminates transmembrane and cytoplasmic tail transcription. (C) Soluble isoforms HLA-G7 generated by an mRNA with a pre-stop codon in intron 2, which terminates the following domain transcription. Sig.peptide, Signal peptide; TMD, transmembrane domain; , stop codon. The superscript capital letter represents amino acid at the position.

Inline graphic — Seven identified HLA-G isoforms generated from its primary transcript alternative splicing. (A) The heavy chain of membrane-bound isoforms HLA-G1, -G2, -G3, -G4 generated by an mRNA containing a stop codon in exon 6. (B) Soluble isoforms HLA-G5 and HLA-G6 generated by an mRNA with a pre-stop codon in intron 4, which terminates transmembrane and cytoplasmic tail transcription. (C) Soluble isoforms HLA-G7 generated by an mRNA with a pre-stop codon in intron 2, which terminates the following domain transcription. Sig.peptide, Signal peptide; TMD, transmembrane domain; , stop codon. The superscript capital letter represents amino acid at the position.