FIGURE 1.

A, Graph depicts mean ACE2 protein expression (colored circles), represented in normalized protein expression (NPX) values, in the serum of the healthy pediatric cohort, healthy adult cohort, AD pediatric cohort, and AD adult cohort. The limit of detection (LOD) for ACE2 protein is shown in the y-axis label. Horizontal bars denote standard error. P-values between adults versus pediatric cohorts are shown. B, Correlation scatterplot between ACE2 protein expression and age in healthy infants and toddlers and healthy adults. Light blue circles denote cohort of infants and toddlers, and dark blue circles denote cohort of adults. Gray shaded area denotes the 95% confidence interval. Spearman’s correlation coefficient and P-value are provided. C, Graph depicts mean ACE2 protein expression (colored circles), represented in normalized protein expression (NPX) values, in the serum of healthy and AD pediatric and adult cohorts by gender. The limit of detection (LOD) for ACE2 protein is shown in the y-axis label. Horizontal bars denote standard error. P-values between various groups are shown. AD, atopic dermatitis; ACE2, angiotensin-converting enzyme 2; NPX, normalized protein expression; LOD, limit of detection