Numbers of patients, N (%) |
458 (83) |
94 (17) |
855 (75.6) |
276 (24.4) |
- |
- |
- |
- |
Age, years±SD |
66±14 |
78±9 |
64±12 |
75±10 |
0.001 |
0.001 |
0.001 |
0.031 |
Hypertension, n/N (%) |
240 (53.7) |
58 (62.4) |
401 (51.9) |
178 (68.5) |
0.12 |
0.001 |
0.001 |
0.21 |
Diabetes, n/N (%) |
62 (13.9) |
18 (19.4) |
160 (19) |
79 (28.9) |
0.17 |
0.001 |
0.001 |
0.23 |
Previous coronary stent, n/N (%) |
15(3.3) |
9 (9.6) |
60 (7) |
35 (12.7) |
0.006 |
0.003 |
0.001 |
0.56 |
Previous CABG, n/N (%) |
2 (3.4) |
5 (1.4) |
27 (4.3) |
17 (10) |
0.28 |
0.004 |
0.001 |
0.12 |
Peripheral artery disease, n/N (%) |
24 (5.4) |
8 (8.6) |
38 (4.5) |
34 (12.5) |
0.23 |
0.001 |
0.001 |
0.52 |
History of atrial fibrillation, n/N (%) |
37 (8.5) |
10 (11) |
54 (6.7) |
45 (16.8) |
0.45 |
0.001 |
0.001 |
0.17 |
Current smoking, n/N (%) |
12 (3.3) |
3 (4.7) |
47 (7.4) |
19 (10.6) |
0.58 |
0.17 |
0.001 |
0.24 |
Chronic lung disease, n/N (%) |
48 (10.8) |
17 (18.3) |
57 (6.8) |
44 (16.1) |
0.043 |
0.001 |
0.037 |
0.56 |
History of oncological malignancy, n/N (%) |
20 (4.5) |
10 (10.8) |
41 (4.9) |
15 (5.5) |
0.016 |
0.68 |
0.53 |
0.045 |
Laboratory |
Hemoglobin, g/dl±SD |
13.1±6 |
12.5±2 |
13.9±2 |
13.2±2 |
0.09 |
0.001 |
0.24 |
0.001 |
White blood cells, n/mm3±SD |
8770±4295 |
10638±3242 |
10312±4778 |
10680±4048 |
0.001 |
0.26 |
0.001 |
0.92 |
Creatinine, mg/dl±SD |
0.9±0.45 |
1.35±0.7 |
1.15±0.61 |
1.6±1 |
0.001 |
0.001 |
0.001 |
0.004 |
CRP, mg/dl±SD |
12.3±15 |
14.9±13 |
16±18 |
16.3±11 |
0.11 |
0.81 |
0.001 |
0.41 |
LDH, U/l±SD |
335±186 |
446±217 |
382±196 |
544±405 |
0.001 |
0.001 |
0.001 |
0.021 |
Baseline troponin, ng/ml±SD |
34±90 |
87±145 |
116±757 |
326±986 |
0.034 |
0.14 |
0.008 |
0.25 |
Oxygen saturation on air, %±SD |
92±5 |
86±9 |
91±8 |
87±9 |
0.001 |
0.001 |
0.001 |
0.7 |
Radiology |
Coronary calcification (CAC), n/N (%) |
223 (48.7) |
58 (61.7) |
516 (60.4) |
197 (71.4) |
0.022 |
0.001 |
0.001 |
0.068 |
Left main, mm3±SD |
10±40 |
48±138 |
20±76 |
39±75 |
0.001 |
0.001 |
0.001 |
0.36 |
LAD, mm3±SD |
62±144 |
128±219 |
131±250 |
238±325 |
0.001 |
0.001 |
0.001 |
0.007 |
LCX, mm3±SD |
27±138 |
88±275 |
62±233 |
124±266 |
0.003 |
0.001 |
0.001 |
0.46 |
RCA, mm3±SD |
47±252 |
93±263 |
98±344 |
257±729 |
0.14 |
0.001 |
0.001 |
0.07 |
CAC volume, mm3±SD |
147±455 |
355±743 |
308±745 |
646±1063 |
0.001 |
0.001 |
0.001 |
0.046 |
Zero calcium score, n/N (%) |
205 (44.8) |
23 (24.5) |
256 (29.9) |
32 (11.6) |
0.001 |
0.001 |
0.001 |
0.004 |
Thoracic aorta calcification, n/N (%) |
339 (74) |
84 (89.4) |
612 (71.6) |
234 (84.8) |
0.001 |
0.001 |
0.001 |
0.33 |
Thoracic aortic calcification, mm3±SD |
1825±3978 |
4209±6022 |
1687±3462 |
4476±6158 |
0.001 |
0.001 |
0.001 |
0.86 |
Aortic valve calcification, n/N (%) |
182 (39.7) |
57 (60.6) |
305 (35.7) |
162 (58.7) |
0.001 |
0.001 |
0.001 |
0.84 |
Aortic valve calcium, mm3±SD |
79±291 |
353±993 |
138±544 |
364±922 |
0.001 |
0.001 |
0.001 |
0.88 |
Pleuric effusion, n/N (%) |
61 (13.3) |
20 (21.3) |
124 (14.5) |
47 (17) |
0.047 |
0.3 |
0.16 |
0.24 |
Pericardial effusion, n/N (%) |
24 (5.2) |
10 (10.6) |
38 (4.4) |
22 (8) |
0.047 |
0.023 |
0.13 |
0.46 |
Interstitial lung involvement >50, n/N (%) |
76 (16.6) |
35 (37.2) |
170 (19.9) |
109 (39.5) |
0.001 |
0.001 |
0.001 |
0.73 |
In-hospital outcomes |
MACEs, n/N (%) |
21 (4.6) |
7 (7.4) |
54 (6.3) |
23 (8.3) |
0.24 |
0.24 |
0.038 |
0.58 |
Stroke, n/N (%) |
6 (1.3) |
3 (3.2) |
10 (1.2) |
7 (2.5) |
0.19 |
0.1 |
0.22 |
0.87 |
Peripheral arterial embolization, n/N (%) |
2 (0.4) |
2 (2.1) |
0 (0) |
10 (3.6) |
0.078 |
0.001 |
0.001 |
0.73 |
Pulmonary embolism, n/N (%) |
13 (2.8) |
2 (2.1) |
34 (4) |
5 (1.8) |
0.69 |
0.087 |
0.38 |
0.81 |
Acute coronary syndrome, n/N (%) |
2 (0.4) |
2 (2.1) |
0 (0) |
10 (3.6) |
0.078 |
0.001 |
0.001 |
0.73 |
NIV without intubation, n/N (%) |
74 (16.2) |
0 (0) |
217 (25.4) |
0 (0) |
0.001 |
0.001 |
0.001 |
- |
Intubation, n/N (%) |
36 (7.9) |
7 (7.4) |
114 (13.3) |
50 (18.1) |
0.89 |
0.05 |
0.001 |
0.023 |