Table 2.
Logistic regression modeling of imaging predictor variables.
| OR (95% CI)a | AUROC | P-value | |
|---|---|---|---|
| Single biomarker predictors | |||
| CIS ratio | 4.06 (1.74, 9.45) | 0.793 | 0.001 |
| Medial Temporal SUVr | 6.37 (2.50, 20.98) | 0.844 | <0.001 |
| Substantia Nigra SUVr | 0.09 (0.02, 0.41) | 0.791 | 0.002 |
| Two biomarker predictors | |||
| CIS ratio + Medial Temporal SUVr | |||
| CIS ratio | 2.67 (1.12, 6.37) | 0.884 | 0.026 |
| Medial Temporal SUVr | 4.33 (1.44, 13.00) | 0.009 | |
| CIS ratio + Substantia Nigra SUVr | |||
| CIS ratio | 4.14 (1.60, 10.67) | 0.875 | 0.003 |
| Substantia Nigra SUVr | 0.10 (0.02, 0.52) | 0.006 | |
| Medial Temporal + Substantia Nigra SUVrs | |||
| Medial Temporal SUVr | 6.60 (1.95, 22.31) | 0.902 | 0.002 |
| Substantia Nigra SUVr | 0.10 (0.02, 0.53) | 0.007 | |
| All three biomarker predictors | |||
| CIS ratio + Medial Temporal + Substantia Nigra SUVrs | 0.921 | ||
| CIS ratio | 2.56 (0.84, 7.78) | 0.097 | |
| Medial Temporal | 3.86 (1.10, 13.49) | 0.035 | |
| Substantia Nigra | 0.13 (0.02, 0.70) | 0.018 |
a
In the logistic regression analysis, the odds ratios are based on 0.10 unit change. MCI-AD is the reference group. When OR is greater than 1 the values are higher in the MCI-DLB and conversely when the OR is<1 then the values are higher in MCI-AD individuals.