FIGURE 4.

KSHV induces circRNA expression post-transcriptionally. (A,B) Exon-wise analysis of read-counts upon KSHV infection in RELL1 (A) and ESYT2 (B) loci. Shown are RPKM (reads per kilobase in million reads) of total RNA Seq (left) and circRNA-Seq (right). Numbers in x-axis corresponds to exon number from 5′ ends. Under each panel, locations of human circRNA in circBase are shown. (C) Exon-wise fold-change of select genes comparing infected and non-infected human primary endothelial cells. Circles are exons that are part of circRNAs and lines are exons that are not known to be circRNAs according to circbase. Only exons with aligned read counts > 0.05 RPKM are shown.