Table 1.
Dog patients with osteosarcoma and high grade sarcoma enrolled in the clinical trial, see also Figure 3
| Treatment | Dog ID | Breed | Sex | Age (years) | Histotype | Anatomic site | Stage | ALP | Carboplatin (cycles) | Vax (autologous/heterologous) | Vax state | TTM | State (alive/dead) | Death related to cancer (Y/N) | Survival (days) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Osteosarcoma | |||||||||||||||
| Carboplatin + VAX | 0 | Newfoundland | F | 7 | osteoblastic | right distal radius | metastases | Wnl | 4 | H | completed | 653+ | D | N | 653 |
| 1 | American staffordshire terrier | F | 12 | osteoblastic | right proximal humerus | Wnl | 4 | A | 5 out of 6 | 214 | D | Y | 224 | ||
| 8 | mixed breed | M | 12 | osteoblastic | right proximal tibia | increased | 4 | A | 5 out of 6 | 229+ | D | N | 229 | ||
| 17 | mixed breed | M | 10 | osteoblastic | left hemibacin | increased | 6 | A | 4 out of 6 | 246+ | D | Y | 246 | ||
| 19 | Rottweiler | F | 7 | osteoblastic | right proximal tibia | Wnl | 4 | A | completed | 551 | D | Y | 621 | ||
| 23 | Spanish greyhound | F | 9 | chondroblastic | right distal femur | Wnl | 4 | A | 5 out of 6 | 306+ | D | N | 306 | ||
| 42 | border collie | F | 7 | osteoblastic | left proximal tibia | Wnl | 4 | H | completed | 281 | D | Y | 630 | ||
| 47 | boxer | F | 12 | osteoblastic | left proximal humerus | Wnl | 4 | H | completed | 589 | D | Y | 649 | ||
| 51 | Leonberger | M | 3 | osteoblastic | scapula | Wnl | 4 | H | completed | 700+ | A | 700+ | |||
| 52 | mixed breed | F | 8 | osteoblastic | right distal radius | Wnl | 4 | H | completed | 701+ | A | 701+ | |||
| Carboplatin |
mixed breed | F | 7 | osteoblastic | proximal femur | no mets |
Wnl | 4 | no VAX | N/A | 111 | D | Y | 131 | |
| Lagotto | M | 3 | chondroblastic | distal femur | Wnl | 6 | no VAX | N/A | 169 | D | Y | 169 | |||
| German shepherd | M | 8 | osteoblastic | proximal humerus | Wnl | 4 | no VAX | N/A | 375 | D | Y | 375 | |||
| mixed breed | F | 5 | osteoblastic | distal radius | Wnl | 6 | no VAX | N/A | 252 | D | Y | 371 | |||
| mixed breed | F | 13 | osteoblastic | proximal humerus | Wnl | 6 | no VAX | N/A | 298 | D | Y | 329 | |||
| mixed breed | F | 11 | osteoblastic | distal radius | Wnl | 6 | no VAX | N/A | 358 | D | Y | 358 | |||
| Rottweiler | M | 1 | osteoblastic | proximal tibia | increased | 4 | no VAX | N/A | 130 | D | Y | 156 | |||
| mixed breed | F | 10 | osteoblastic | distal tibia | Wnl | 4 | no VAX | N/A | 75 | D | Y | 162 | |||
| pitbull | F | 13 | osteoblastic | distal femur | increased | 4 | no VAX | N/A | 278 | D | Y | 278 | |||
| German shepherd |
M |
9 |
osteoblastic |
distal radius |
Wnl |
6 |
no VAX |
N/A |
351 |
D |
Y |
369 |
|||
| Sarcoma | |||||||||||||||
| Carboplatin +VAX | 5 | pitbull | F | 6 | soft tissue sarcoma | hind limb | no mets | Wnl | 4 | A | completed | 2,224+ | D | N | 2,224 |
| sarcoma relapse | hind limb | A | completed | ||||||||||||
| 32 | beagle | F | 10 | soft tissue sarcoma | abdomen | no mets | Wnl | 4 | A | 4 out of 6 | 244+ | D | Y | 244 | |
| 35 | cocker spaniel | F | 4 | soft tissue sarcoma | gingiva | no mets | Wnl | 4 | A | completed | 1,516+ | A | 1,516+ | ||
Wnl, within normal levels.