Table 6.
SPMs and SPM mimetics tested in human.
| SPMs | Analog/Receptor agonist | Clinical trials | Effects | References |
|---|---|---|---|---|
| RvE1 | RX-10045 (analog) | Combined Phase I and II in patients with dry eye symptoms | Safe and well tolerated | NCT00799552 |
| LXA4 | 15(R/S)‐methyl‐lipoxin A4 (analog) | Study in Infantine eczema | Well tolerated Reduction of eczema severity |
(198) |
| LXA4 | BLXA4-ME (analog) | Phase I/II in patients with gingivitis (on going) | Assess safety and preliminary efficacy | NCT02342691 |
| LXA4 | LXA4 (native) | Study in patients with asthma | LXA4 attenuated leukotriene C4-induced bronchoconstriction | (199) |
| LXA4 | 5(S),6(R)-LXA4 methyl ester (analog), BML-111 (agonist) |
Pilot study in asthmatic children | Safe and well tolerated Improvement of pulmonary functions |
(200) |