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. 2020 Oct 5;8(5):603–622. doi: 10.1016/j.gendis.2020.09.006

Figure 1.

Fig. 1

Characteristics and progression of piRNAs. (A) The milestone events in the piRNA field. (B) piRNAs show distinct characteristics different from miRNAs and siRNAs, from genome source to RISC formulation and gene silencing style. Abbreviation: EV, exosome vesicle; MM, Multiple myeloma; PTGS, post-transcriptional gene silencing; PTGA, post-transcriptional gene activation; TGA, transcriptional gene activation; TGS, transcriptional gene silencing; H3K9me3, trimethylation of H3 lysine 9; UTR, untranslated region; RISC, RNA-induced silencing complex.