Table 3.
Genes identified by SimPo score to reflect the DNA methylation remodeling in insulin resistance and depression.
| No. | Gene | p-value (IR vs. Ctrl) | p-value (Depression vs. Ctrl) | Nutraceutical targeting the protein |
|---|---|---|---|---|
| 1 | CTNS | 0.000155 | 0.002457 | Cystine |
| 2 | P4HTM | 0.000427 | 0.357627 | Ascorbic acid |
| 3 | VDR | 0.000935 | 0.010636 | Calcitriol, Calcifediol, Ergocalciferol, Cholecalciferol, Alfacalcidol, Vitamin D |
| 4 | AADAT | 0.000955 | 0.355463 | Pyridoxal Phosphate, Glutamic Acid |
| 5 | BCAT2 | 0.00112 | 0.87388 | Pyridoxal Phosphate, Glutamic Acid, l-Leucine, l-Isoleucine |
| 6 | PDCD6 | 0.001821 | 0.357192 | Calcium |
| 7 | RARA | 0.002744 | 0.012328 | Tretinoin |
| 8 | GRID1 | 0.003623 | 0.059968 | Glutamic Acid |
| 9 | NQO2 | 0.004228 | 4.65E-07 | NADH, Menadione, Melatonin |
| 10 | SGPL1 | 0.006147 | 0.005774 | Pyridoxal Phosphate |
| 11 | PPIH | 0.008855 | 0.331482 | Proline |
| 12 | GSTO2 | 0.012418 | 0.29847 | Glutathione |
| 13 | ADK | 0.012601 | 0.079088 | Adenosine phosphate |
| 14 | AHR | 0.027996 | 0.951787 | Ginseng |
| 15 | GRM8 | 0.039308 | 0.460064 | Glutamic Acid |
P1: SimPo-score-based t-test p-value for insulin resistance vs. healthy individual.
P2: SimPo-score-based t-test p-value for depression vs. healthy individual.