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. 2020 Jul 16;8(5):629–639. doi: 10.1016/j.gendis.2020.07.002

Figure 5.

Figure 5

Treatment of defective mitochondria. This figure represents the possible therapeutic techniques that can be used for the treatment of defective mitochondria. When defects in ETC is observed, correct tRNAs can be imported through gene technology into the mitochondria. These tRNAs will replicate using the cellular machinery providing correct proteins; PPAR ligands can be introduced to increase the replication of mitochondrial genes to enhance the availability of suitable genes; antigenomic drugs can also be administered to inhibit replication of defective genes in the mitochondria.