Table 2.

The effect of microenvironment on LPCs.

Factors	Source	Function	References
EVs	stromal lines	maintains the survival and clonogenic potential of HSPCs	15
Cytokines	Niche cells	LPCs activation, proliferation and differentiation	16, 19,31
Laminin	Extracellular matrix	LPCs proliferation and differentiation	24
collagen type I	Extracellular matrix	LPCs proliferation and differentiation	23,30,31
collagen types III	Extracellular matrix	LPCs proliferation	31
collagen types IV	Extracellular matrix	LPCs proliferation	31
1-like matrix proteins	Extracellular matrix	LPCs proliferation	31
3-like matrix proteins	Extracellular matrix	LPCs differentiation;	31
Matrix stiffness	Extracellular matrix	LPCs survival or adhesion	35