Table 1.
Gene regulated by lncRNAs and miRNAs in NK cell development.
LncRNA/MiRNA | Target gene | Model | Biological significance | Reference |
---|---|---|---|---|
lnc-CD56 | CD56 | human | enhances the expression of CD56 | 42 |
miR-583 | IL-2Rγ | human | acts as a negative regulator of NK cell differentiation by silencing IL2Rγ | 46 |
miR-181 | Nemo-like kinase | human | promotes NK cell development through the suppression of Nemolike-kinase | 45 |
Rroid | Id2 | mouse | regulates the function and lineage identity of NK cells | 41 |
miR-29b | TBET, EOMES | mouse | deletion of miR-29b in NK cells reverses the depletion of NK cell subset in leukemic mice | 47 |
miR-150 | c-Myb | mouse | differentially controls the development of NK cell lineages by targeting c-Myb | 44 |
miR-15/16 | c-Myb | mouse | miR-15/16 regulation of Myb controls the NK cell maturation program | 43 |