Table 3.

Gene regulated by lncRNAs and miRNAs in NK cell function.

Cytotoxic molecules	LncRNA/MiRNA	Target gene	Biological significance	References
Granzyme B	miR-362–5p	CYLD	enhances the expression of granzyme-B via NK-κB pathway	68
	miR-223	GzmB	contributes to control of GzmB translation in resting NK cells	74
	miR-27a	GzmB	suppresses NK-cell cytotoxicity by silencing GzmB expression	71
	miR-378	GzmB	suppresses GrzB expression in NK cells	72
	miR-30e	GzmB	suppresses GrzB expression in NK cells	73
	miR-23a	CTSC	decreases CTSC expression and granzyme B activity	75
Perforin	miR-362–5p	CYLD	enhances the expression of perforin via NK-κB pathway	68
	miR-27a	Prf1	silences Prf1 expression in NK cells	71
	miR-30e	Prf1	suppresses Prf1 expression in NK cells	73
	miR-150	Prf1	represses NK cell lytic activity by targeting perforin-1	44
	miR-378	miR-378	inhibites GrzB expression in DENV-infected patients	74
TNF-a	miR-146a	STAT1	negatively regulates TNF-α expression via STAT1 signaling	87
	miR-30c-1	hmbox1	enhances NKL cell cytotoxicity through up-regulation of TNF-α	64
IFN-γ	lncRNA GAS5	miR-544/RUNX3	increases RUNX3 expression and IFN-γ secretion	69
	lncRNA IFNG-AS1	/	induces upon NK cell activation and increases IFNγ secretion	66
	miR-155	SHIP-1/Noxa	increase IFN-γ production in HCV-infected patients	95
	miR-155	Tim-3	regulates IFN-γ production in NK cells via Tim-3 signalling	96
	miR-146a	STAT1	negatively regulates IFN-γ expression via STAT1 signaling	98
	miR-362–5p	CYLD	enhances the expression of IFN-γ via NK-κB pathway	68
	miR-34a	/	enhances cytolysis and interferon-γ production by NK-92MI cells	55
	miRNA-29b	DNMTs	regulates INF-γ expression via decreasing methylation of IFN-γ	99
	miR-15/16	c-Myb	enhances the expression of granzyme-B in NK cells	43